![]() Here we show that prion-like low complexity regions (LCRs) enable avid CPSF6, NUP153 and SEC24C binding to capsid lattices. While weak interactions of short phenylalanine-glycine (FG) containing peptides with isolated capsid hexamers have been characterized, how these cellular factors functionally engage with biologically relevant mature HIV-1 capsid lattices is unknown. ![]() Nature Communications volume 13, Article number: 5879 ( 2022)Ĭellular proteins CPSF6, NUP153 and SEC24C play crucial roles in HIV-1 infection. ![]() Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection
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